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Wang Dan Ji Bo Zhao Guozhen Yan Mingna Bai Hongxin Sun Xiaomin Dai Jian Lu Yawen Liu Yitian You Min Wu Jiaojuan Ge Yunpeng Su Hang Cheng Kai 《中医杂志(英文版)》2017,37(6):794-803
Objective
To investigate the effect of electroacupuncture (EA) of acupoints Neiguan (PC 6) and Tianquan (PC 2) on the skin temperature, blood perfusion, and alpha1- and beta2-adrenoreceptor (α1-AR and β2-AR) protein and mRNA level in rats with acute myocardial ischemia.Methods
Thirty male adult Wistar rats [(230 ± 20) g] were randomly assigned into five groups (n = 6 each): a control group, sham operation group, model group, model group treated with EA at low frequency (L-EA, 2 Hz, 1 mA) and model group treated with EA at high frequency (H-EA, 100 Hz, 1 mA). The rat model was prepared by ligating the left anterior descending coronary artery. Electroacupuncture was performed at the left Neiguan (PC 6) for 20min daily for 3 d. After the 3rd time of the treatment, measurements of skin blood perfusion and temperature in Neiguan (PC 6) and Tianquan (PC 2) in all groups were made by laser speckle contrast imaging and infrared thermal image instrument. Real-time PCR and ELISA were used to measure mRNA level and protein level of α1-AR and β2-AR in the skin tissues of Neiguan (PC 6) and Tianquan (PC 2), respectively. Serum levels of cTnT and electrocardiogram were used to identify the state of myocardium.Results
In the group receiving electroacupunture at Neiguan (PC 6), compared with control group, the skin temperature, blood perfusion, and β2-AR mRNA and protein level of model group significantly decreased (P < 0.05), α1-AR mRNA and protein level of model group significantly increased (P < 0.05); compared with model group, the skin temperature, blood perfusion, and β2-AR mRNA and protein level of L-EA significantly increased (P < 0.05), α1-AR mRNA and protein level of L-EA and H-EA significantly decreased (P < 0.05). The same trend has taken place in the former four groups of the Tianquan (PC 2).Conclusion
Low-or high-frequency electroacupuncture can improve the skin temperature and blood perfusion which may be induced by decreasing the level of α1-AR and increasing the level of β2-AR of the Neiguan (PC 6) and Tianquan (PC 2) in the rat with acute myocaidial ischemia. 相似文献2.
BackgroundThe effects of acupuncture on in-vitro fertilization outcomes remain controversial. This study aimed to perform a meta-analysis to assess the effectiveness of acupuncture as an adjuvant therapy to embryo transfer compared to sham-controls or no adjuvant therapy controls on improving pregnancy outcomes in women undergoing in-vitro fertilization.MethodsA systematic literature search up to January 2021 was performed and 29 studies included 6623 individuals undergoing in-vitro fertilization at the baseline of the study; 3091 of them were using acupuncture as an adjuvant therapy to embryo transfer, 1559 of them were using sham-controls, and 1441 of them were using no adjuvant therapy controls. They reported a comparison between the effectiveness of acupuncture as an adjuvant therapy to embryo transfer compared to sham-controls or no adjuvant therapy controls on improving pregnancy outcomes in women undergoing in-vitro fertilization. Odds ratio (OR) with 95% confidence intervals (CIs) were calculated assessing the effectiveness of acupuncture as an adjuvant therapy to embryo transfer compared to sham-controls or no adjuvant therapy controls using the dichotomous method with a random or fixed-effect model.ResultsSignificantly higher outcomes with acupuncture were observed in biochemical pregnancy (OR, 1.98; 95% CI, 1.55–2.53, p < 0.001); clinical pregnancy (OR, 1.70; 95% CI, 1.46–1.98, p < 0.001); ongoing pregnancy (OR, 1.78; 95% CI, 1.41–2.26, p < 0.001); and live birth (OR, 1.58; 95% CI, 1.15–2.18, p = 0.005) compared to no adjuvant therapy controls. However, no significant difference were found between acupuncture and no adjuvant therapy controls in miscarriage (OR, 0.96; 95% CI, 0.48–1.92, p = 0.91).No significant difference was observed with acupuncture in biochemical pregnancy (OR, 1.16; 95% CI, 0.65–2.08, p = 0.62); clinical pregnancy (OR, 1.13; 95% CI, 0.83–1.54, p = 0.43); ongoing pregnancy (OR, 1.04; 95% CI, 0.66–1.62, p = 0.87); live birth (OR, 1.02; 95% CI, 0.73–1.42, p = 0.90), and miscarriage (OR, 1.16; 95% CI, 0.86–1.55, p = 0.34) compared to sham-controls.ConclusionsUsing acupuncture as an adjuvant therapy to embryo transfer may improve the biochemical pregnancy, clinical pregnancy, ongoing pregnancy, and live birth outcomes compared to no adjuvant therapy controls. However, no significant difference was found between acupuncture as an adjuvant therapy to embryo transfer and sham-controls in any of the measured outcomes. This relationship forces us to recommend the use of acupuncture as adjuvant therapy in women undergoing in-vitro fertilization and inquire further studies comparing acupuncture and sham-controls to reach the best procedure. 相似文献
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目的目前紧张的工作状态和激烈的社会竞争压力等应激源日益泛化,由此导致的身心疾病已严重影响人的生存质量。临床观察电针对应激性精神心理疾病具有明显疗效。文中旨在通过观察电针不同穴位对束缚应激模型大鼠行为改变的影响,进一步探讨免疫失调状态下心理行为的改变及电针的调节作用。方法将50只雄性Wistar大鼠随机分为正常组、模型组、电针百会组、电针关元组、电针足三里组,每组10只。除正常组外,余各组均采用自制布袋束缚大鼠30 min,每天1次,共20 d制备束缚应激大鼠模型,于造模第2天,各治疗组捆绑固定后给予电针20 min,隔天1次,共10次。于造模前、造模后、治疗5次及10次,分别采用高架十字迷宫(elevated plus-maze,EPM)检测各组大鼠进入开放臂次数(open arm entry,OE)比例及停留开放臂时间(open arm time,OT)比例的变化。结果与造模前比较,造模后电针百会组大鼠OT比例降低明显、电针关元组大鼠OE比例升高明显,电针足三里组大鼠造模后、治疗5次后OT比例均明显降低,治疗10次后大鼠OE比例则明显升高,P<0.01;与造模刚结束比较,治疗5次后电针百会组大鼠OT比例明显升高(P<0.05),电针关元组大鼠OE比例明显降低、电针足三里组治疗10次后模型大鼠OE和OT比例均升高明显(P<0.01);与治疗5次比较,治疗10次后电针关元组大鼠OE比例升高明显(P<0.05),电针足三里组大鼠OE和OT比例均明显升高(P<0.01)。电针各组间比较,大鼠在治疗5次、10次后OE和OT比例呈不同程度的升高或降低趋势,差异无统计学意义(P>0.05)。结论电针介入具有一定抗抑郁和抗焦虑作用,可改善慢性束缚应激所引起的抑郁、情绪焦虑;百会、关元、足三里穴均具有抗焦虑作用,且不同穴位效应不同,百会在应激早期的抗焦虑作用明显,而关元、足三里穴的作用较为稳定、持久。 相似文献
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目的:探讨建立寒凝证动物模型的最佳温度条件。方法:将50只雌性SD大鼠随机分为A、B、C、D、E 5组,每组10只,A组为对照组,B、C组为-15℃冷冻组,D、E组为-25℃冷冻组,各组均冷冻5 d,每天冷冻4 h。C、E组同样冷冻后,正常喂养5 d。观察大鼠体征和体重,在冷冻结束后第1天和第5天取血检测血液流变学指标。结果:与A组比较,B、C、D、E组大鼠体征变化评分均明显升高,P<0.05;与A组比较,B组和D组冷冻期内大鼠体重下降,P<0.05,E组冷冻结束后体重增加较少,P<0.05;与A组比较,B组与D组全血还原黏度高切明显升高,P<0.05,红细胞刚性指数有升高趋势,但未见统计学差异。结论:每天-25℃、4 h,连续冷冻5 d,可建立寒凝证模型,结合整体体征评分及血液流变学指标评价,符合中医寒凝证候特点。 相似文献
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目的 评价经筋针刺法和常规针刺法治疗膝骨关节炎的临床疗效。方法 计算机检索中国知网、万方、维普、Cochrane临床对照试验中心注册库及PubMed数据库，收集建库至2019年4月25日发表的有关经筋针刺法治疗膝骨关节炎的随机对照试验（RCT），将收集到的文献进行筛选，并由两名评价者独立提取资料和评价文献质量后采用RevMan 5.3软件进行Meta分析。结果 共纳入31个随机对照试验，涉及2321例患者。Meta分析结果显示：经筋针刺法总有效率优于常规针刺法,其合并的有效率RR值及95%CI为RR = 1.21，95%CI（1.16，1.25）。WOMAC疼痛、僵硬、日常生活难度评分均优于常规针刺法，其各项评分的SMD值及95%CI分别为：SMD = -2.03,95%CI [-2.37,-1.70]；SMD = -0.20,95%CI[-0.42,-0.02]；SMD = -0.70，95%CI[-0.96,-0.44]。结论 因为经筋针刺法减张效果强于常规针刺，能迅速缓解疼痛和运动功能障碍，所以经筋针刺法对KOA疗效优于常规针刺法。 相似文献
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目的探索武汉抗疫1号方治疗武汉社区隔离状态发热人群的疗效,分析中医药在“武昌模式”中防治新冠肺炎的效果。方法采用病例系列报告的方法,对武汉地区多个社区隔离状态发热人群进行观察性研究;通过“渔歌医疗平台”记录患者相关信息和诊疗数据,以发热治愈时间和治愈率为主要疗效指标,分析武汉抗疫1号方对隔离状态发热人群的疗效。结果纯中药武汉抗疫1号方的疗效优于非纯武汉抗疫1号方人群,纯中药武汉抗疫1号方发热中位治愈时间为1 d、治愈率为82.7%,非纯中药组治疗发热中位治愈时间为2 d、治愈率为62.7%,差异有统计学意义(P<0.05)。4类发热人群使用纯中药武汉抗疫1号方治疗,发热中位治愈时间均为1 d,治愈率:状态不明者66.7%、密切接触者75.0%、疑似病例80.8%、确诊病例92.6%。对于确诊病例,使用纯中药武汉抗疫1号方与非纯中药的发热中位治愈时间均为1 d,治愈率分别为92.6%、75.5%。结论纯中药武汉抗疫1号方对于隔离状态发热人群的疗效优于非纯中药组,1 d可以看到明显的退热效果;其具有“通用方”的特性,不仅对确诊病例有效,也适合疑似病例、密切接触者的防治,为武汉抗疫1号方治疗新冠肺炎提供了证据。 相似文献
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目的：评价铍针治疗腰椎间盘突出合并臀部筋结病变的临床疗效。方法：2009年8月至2010年2月,将符合纳入标准的83例（男29例,女54例）腰椎间盘突出合并臀部筋结病变的患者随机分为铍针组和针刺组。铍针组采用铍针治疗,垂直点刺法进针,铍针疾刺疾出,不捻转,进针深度以通过筋结表层为度,2次为1个疗程;针刺组采用针刺治疗,穴位选用阿是穴,即条索样包块或筋结等压痛点处,进针后寻找沉紧滞涩的针感,留针20min,10次为1个疗程。末次治疗后即时进行VAS评分。末次治疗后3d复查B超。观察指标为两组治疗前后VAS评分变化和筋结的B超炎性反应带宽度变化。结果：臀部筋结病变的B超表现为炎性反应带或筋结,治疗后两组B超炎性反应带宽度均明显减小,差异无统计学意义（P=0.635）。比较两组B超炎性反应带宽度变化的差值,无统计学意义（P=0.813）。结论：铍针疗法对臀部筋结病变的减张、减压效果优于针刺疗法。B超给出了臀部筋结病变的形态学表现,其内容物为低回声的炎性渗出。B超对臀部筋结病变的诊断、形态学方面的治疗作用及疗效判定有肯定意义。 相似文献
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